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Twenty years of research on silica‐based chiral stationary phases
Author(s) -
Cancelliere Giovanna,
D'Acquarica Ilaria,
Gasparrini Francesco,
Maggini Michele,
Misiti Domenico,
Villani Claudio
Publication year - 2006
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200500517
Subject(s) - enantioselective synthesis , chiral stationary phase , stationary phase , nanotechnology , computer science , chemistry , combinatorial chemistry , materials science , enantiomer , chromatography , organic chemistry , catalysis
This review provides an overview of twenty years of pioneering work (from 1985 to 2005) of our research group in the preparation and application of enantioselective packing materials for HPLC. After a brief introduction to the rational design of a new chiral stationary phase, a detailed presentation in chronological order of appearance in the literature is given of the currently developed repertoire of chiral stationary phases and their typical applications. Emphasis is placed on the different synthetic strategies exploited to obtain highly efficient, stable, and versatile chiral stationary phases.