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Urea bonded cyclodextrin derivatives onto silica for chiral HPLC
Author(s) -
Muderawan I. Wayan,
Ong TengTeng,
Ng SiuChoon
Publication year - 2006
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200500491
Subject(s) - cyclodextrin , chemistry , enantiomer , high performance liquid chromatography , urea , chiral column chromatography , chromatography , resolution (logic) , organic chemistry , combinatorial chemistry , artificial intelligence , computer science
Abstract Several structurally well‐defined perfunctionalised cyclodextrin chiral stationary phases (CD CSPs) for high performance liquid chromatography have been successfully prepared by immobilisation of perfunctionalised cyclodextrins on silica through urea linkage(s) using the Staudinger reaction. These CSPs show high chiral recognition efficiency and are utilised in the resolution of various types of racemic compounds. This paper reviews the development of sixteen perfunctionalised cyclodextrin‐based CSPs, their preparation, and their application to enantioseparation of seventy‐seven racemic compounds under a range of separation conditions.