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A (4 R )‐Hydroxy‐ L ‐proline‐derived chiral scaffold and its oligomers as chiral selectors in liquid chromatography chiral stationary phases for enantioseparation
Author(s) -
Sancho Raquel,
Pérez Anna M.,
Minguillón Cristina
Publication year - 2006
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200500484
Subject(s) - proline , chemistry , monomer , chiral column chromatography , chiral stationary phase , chromatography , high performance liquid chromatography , phase (matter) , alcohol , combinatorial chemistry , amino acid , organic chemistry , polymer , biochemistry
The chromatographic behaviour of a poly‐ L ‐proline‐derived chiral stationary phase (CSP) is compared to the corresponding single proline‐derived CSP. Structurally diverse racemic test compounds and mobile phases, including normal‐ and RP conditions, were used. Although the application domain of the poly‐ L ‐proline‐derived CSP (CSP‐3) was considerably restricted, this CSP showed a higher retention and a slightly broader application domain than the monomeric analogue (CSP‐1) when heptane/2‐PrOH was used as mobile phase. The presence of an alcohol in the mobile phase was essential for enantioseparation in the poly‐ L ‐proline‐derived CSP when normal‐phase conditions were applied.