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Preparation and application of HPLC chiral stationary phases based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid
Author(s) -
Hyun Myung Ho
Publication year - 2006
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200500431
Subject(s) - chemistry , aqueous solution , 18 crown 6 , high performance liquid chromatography , amino acid , covalent bond , resolution (logic) , chiral stationary phase , phase (matter) , chromatography , combinatorial chemistry , organic chemistry , molecule , biochemistry , artificial intelligence , computer science
Preparation of liquid chromatographic chiral stationary phases (CSPs) based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid and their application are reviewed. The various methods of connecting (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid to silica gel covalently or dynamically are demonstrated. The CSPs based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid have been very successful for the resolution of various primary amino compounds with the use of an aqueous mobile phase containing organic and acidic modifiers. In addition, the resolution of secondary amino compounds including β‐blockers and N ‐(3,5‐dinitrobenzoyl)‐α‐amino acids has been demonstrated on a CSP based on (+)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid with a non‐aqueous mobile phase.