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Supramolecular systems‐based extraction‐separation techniques coupled to mass spectrometry
Author(s) -
Merino Francisco,
Rubio Soledad,
PérezBendito Dolores
Publication year - 2005
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200500161
Subject(s) - supramolecular chemistry , chemistry , bioanalysis , mass spectrometry , extraction (chemistry) , solid phase extraction , chromatography , capillary electrophoresis , nanotechnology , organic chemistry , materials science , molecule
The combination of supramolecular chemistry and MS has not only been fruitful in the field of gas‐phase fundamental studies of host–guest complexes and supramolecular assemblies. Mass spectrometric analysis has also benefited from the ability of supramolecular systems to behave as pseudophases in which solutes partition from the bulk solvent phase. Supramolecular systems‐based extraction and concentration schemes and separation techniques have been widely used in different fields of analytical chemistry and are ideally suited for coupling with MS. This review describes the present status of the application of supramolecular chemistry in mass spectrometric analysis and includes topics such as the use of coacervative liquid–liquid extraction and hemimicelle/admicelle‐based SPE of organic compounds prior to chromatography and electrophoresis. It also discusses the recent advances in enantioselective analysis using CD in electrophoresis‐ and chromatography‐MS. The potential and analytical challenges of these approaches in environmental and bioanalytical chemistry, where one can expect significant developments in the future, are outlined.