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Selectivity of amylose tris(3,5‐dimethylphenyl‐carbamate) chiral stationary phase as a function of its structure altered by changing concentration of ethanol or 2‐propanol mobile‐phase modifier
Author(s) -
Helmy Roy,
Wang Tao
Publication year - 2005
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200401892
Subject(s) - chemistry , enantiomer , selectivity , ethanol , propanol , phase (matter) , carbamate , solvent , alcohol , chromatography , organic chemistry , catalysis
In a previous publication, solid‐state NMR data showed that the structure of Chiralpak AD chiral stationary phase (CSP) was altered by changing the concentration of ethanol or 2‐propanol modifier in the chromatographic mobile phase. This present paper reports the effect of the CSP structural change on chiral selectivity α. The enantiomers of a series of compounds were chromatographed using ethanol or 2‐propanol in various concentrations as mobile‐phase modifier and the α values were determined. Changes of α were observed for some enantiomeric pairs when ethanol and 2‐propanol concentrations were varied. These data correlate with previous findings on the structural changes of the CSP. Not every enantiomeric pair showed changes in α as the alcohol concentration was varied, indicating that the chiral selectivity depends not only on the CSP's structure, but also on the structures of the analytes.