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Molecularly imprinted polymers: A new tool for separation of steroid isomers
Author(s) -
Szumski Michał,
Buszewski Bogusław
Publication year - 2004
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200401799
Subject(s) - molecularly imprinted polymer , steroid , chemistry , chromatography , polymer , selectivity , organic chemistry , biochemistry , hormone , catalysis
Molecularly imprinted polymers hold great promise for the separation of chiral compounds. A non‐covalent approach to the synthesis of MIPs relies on the presence of specific and non‐specific interactions, which lead to the formation of a molecular imprint. The structural differences between 17‐α‐estradiol and 17‐β‐estradiol are too small to permit their efficient separation on a MIP prepared with β‐estradiol as a template. Molecular modeling revealed the presence of only one hydrogen bond that differentiates the two isomers.