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Rapid and sensitive determination of morphine in street opium samples by thermal desorption gas chromatography using a microfurnace pyrolyzer
Author(s) -
Hida Minemasa,
Mitsui Toshiyuki,
Tsuge Shin,
Ohtani Hajime
Publication year - 2004
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200401767
Subject(s) - opium , chromatography , thermal desorption , chemistry , gas chromatography , morphine , relative standard deviation , desorption , analytical chemistry (journal) , detection limit , anesthesia , organic chemistry , medicine , adsorption , political science , law
Thermal desorption of the alkaloids in opium samples at 300°C using a vertical microfurnace pyrolyzer was followed by their on‐line gas chromatographic (GC) analysis on a large‐bore glass capillary column. This method permitted rapid and sensitive determination of the content of the main alkaloid, morphine, in the small (ca. 100 μg) opium samples with a relative standard deviation within 4% for 5 runs. The observed morphine contents of about 12 to 15 w/w % in the given opium samples were in fairly good agreement with those estimated by a conventional GC‐MS method.