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Synthesis and characteristics of composite chiral stationary phases based on cellulose derivatives
Author(s) -
Chen Xiaoming,
Zou Hanfa,
Ni Jianyi,
Feng Shun
Publication year - 2003
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200390010
Subject(s) - cellulose , chemistry , coating , molecule , mixing (physics) , silica gel , composite number , organic chemistry , chemical engineering , materials science , composite material , physics , quantum mechanics , engineering
Composite chiral stationary phases (CSPs) were prepared on the basis of cellulose derivatives coated or bonded onto silica. “Molecular exterior” type CSPs were prepared by mixing together two different cellulose tris‐derivatives before or after being coated or bonded onto silica, and the “molecular interior” type was obtained by synthesizing non‐regioselectively heterosubstituted cellulose derivatives coated or bonded onto silica. For the sake of comparison, the individual phases were also prepared with corresponding cellulose derivatives by coating or bonding approaches, respectively. All of the prepared CSPs were characterized and their chiral recognition properties were evaluated by HPLC with several test racemates. The experimental results demonstrated that the “molecular exterior” CSPs generally exhibit chiral recognition capacities intermediate between those of the two individual phases. However, in the separation of some racemates higher enantioselectivity may be achieved on the “molecular interior” phases than on individual phases, thus broadening the application range of a single cellulose‐based CSP.