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GC‐FID/MS method for the impurity profiling of synthetic d‐allethrin
Author(s) -
Bragieri Matteo,
Liverani Alessandra,
Zanotti Maria Cristina,
Borzatta Valerio,
Fiori Jessica,
Cavrini Vanni,
Andrisano Vincenza
Publication year - 2004
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200301606
Subject(s) - impurity , detection limit , chromatography , chemistry , reproducibility , mass spectrometry , analytical chemistry (journal) , resolution (logic) , organic chemistry , artificial intelligence , computer science
A GC/FID/MS method was developed for the identification and quantification of d‐alle thrin (DA) and its major impurities in commercial samples. Optimisation of the experimental conditions was carried out considering such important requirements as resolution, reproducibility, detection limits of 0.1% ( m/m ) for the impurities, and short analysis time. Under the optimised final conditions the method was validated for specificity, precision (CV% = 0.133 at 2.10 mg/mL and CV% = 0.035 at 3.00 mg/mL), linearity (0–3.00 μg injected), limits of detection (0.09 ng injected) and quantitation (0.28 ng injected), and robustness. The DA related impurities were identified by using a GC/MS method with ion trap mass detection and also by comparison with synthesised standards. The most abundant impurities were crysolactone, allethrolone, chrysanthemic acid, and chloro‐derivatives of DA.