Selectivity tuning of cyclodextrin derivatives by specific substitution | Zendy

Junge Melanie | Zendy; König Wilfried A. | Zendy

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Selectivity tuning of cyclodextrin derivatives by specific substitution

Author(s) -

Junge Melanie,

König Wilfried A.

Publication year - 2003

Publication title -

journal of separation science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.72

H-Index - 102

eISSN - 1615-9314

pISSN - 1615-9306

DOI - 10.1002/jssc.200301604

Subject(s) - substitution (logic) , selectivity , cyclodextrin , chemistry , combinatorial chemistry , chromatography , organic chemistry , computer science , catalysis , programming language

A new, highly enantioselective cyclodextrin derivative combining the properties of heptakis(6‐ O ‐ tert ‐butyldimethylsilyl‐2,3‐di‐ O ‐methyl)‐β‐cyclodextrin and heptakis(2,3‐di‐ O ‐acetyl‐6‐ O ‐ tert ‐butyldimethylsilyl)‐β‐cyclodextrin was prepared by exchanging a methyl group for an acetyl substituent in a single glucose unit of heptakis(6‐ O ‐ tert ‐butyldimethylsilyl‐2,3‐di‐ O ‐methyl)‐β‐cyclodextrin. A comparative evaluation of the separation capabilities showed that the enantioselectivity of both “parent” cyclodextrin derivatives is transferred to the new chiral stationary phase.

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