Open AccessElectrospinning and 3D bioprinting for intervertebral disc tissue engineering
Author(s) -
Pieri Andrea,
Byerley Ann M.,
Musumeci Catherine R.,
Salemizadehparizi Fatemeh,
Vanderhorst Maya A.,
WuertzKozak Karin
Publication year - 2020
Publication title -
jor spine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
0ISSN - 2572-1143
DOI - 10.1002/jsp2.1117
Subject(s) - intervertebral disc , electrospinning , tissue engineering , biofabrication , degeneration (medical) , 3d bioprinting , extracellular matrix , scaffold , biomedical engineering , medicine , materials science , anatomy , pathology , biology , microbiology and biotechnology , composite material , polymer
Intervertebral disc (IVD) degeneration is a major cause of low back pain and represents a massive socioeconomic burden. Current conservative and surgical treatments fail to restore native tissue architecture and functionality. Tissue engineering strategies, especially those based on 3D bioprinting and electrospinning, have emerged as possible alternatives by producing cell‐seeded scaffolds that replicate the structure of the IVD extracellular matrix. In this review, we provide an overview of recent advancements and limitations of 3D bioprinting and electrospinning for the treatment of IVD degeneration, focusing on future areas of research that may contribute to their clinical translation.