Clinical significance of cathepsin D assay in breast cancer tissues | Zendy

Itoh Yukashi | Zendy; Kobayashi Shunzo | Zendy; Iwase Hirotaka | Zendy; Yamashita Hiroko | Zendy; Kuzushima Tatsuya | Zendy; Iwata Hiroji | Zendy; Yamashita Toshinari | Zendy; Naitoh Akihiro | Zendy; Itoh Kazuko | Zendy; Masaoka Akira | Zendy

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Clinical significance of cathepsin D assay in breast cancer tissues

Author(s) -

Itoh Yukashi,

Kobayashi Shunzo,

Iwase Hirotaka,

Yamashita Hiroko,

Kuzushima Tatsuya,

Iwata Hiroji,

Yamashita Toshinari,

Naitoh Akihiro,

Itoh Kazuko,

Masaoka Akira

Publication year - 1995

Publication title -

journal of surgical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.201

H-Index - 111

eISSN - 1096-9098

pISSN - 0022-4790

DOI - 10.1002/jso.2930600402

Subject(s) - cathepsin d , breast cancer , medicine , univariate analysis , oncology , pathology , immunohistochemistry , cancer , lymph node , estrogen receptor , cancer research , multivariate analysis , biology , enzyme , biochemistry

Cathepsin D was assayed in 74 primary breast cancer specimens by enzyme immunoassay (EIA) and immunohistochemical assay (ICA). Of the 74 specimens, 38 (51.4%) were scored positive by ICA, and 25 (33.8%) were scored positive by EIA. The coincidence rate between ICA and EIA was 71.6% (53/74). There was no significant correlation between cathepsin D and menopausal status, tumor size, number of metastatic lymph nodes, histologic type of the tumor, or steroid receptor status. Cathepsin D status designated by EIA or ICA predicted neither disease‐free survival (DFS) nor overall survival (OAS). Subset analysis with estrogen receptor, menopausal, and lymph node status revealed no association between cathepsin D and survival. Univariate analysis revealed no association between cathepsin D and DFS or OAS. Therefore, cathepsin D is not an independent prognostic factor in breast cancer. © 1995 Wiley‐Liss, Inc.

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