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Intraoperative radiation therapy for locally advanced recurrent rectal or rectosigmoid cancer
Author(s) -
James Iii H. Wallace,
Willett Christopher G.,
Shellito Paul C.,
Coen John J.,
Hoover Herbert C.
Publication year - 1995
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930600211
Subject(s) - medicine , surgery , radiation therapy , colorectal cancer , rectum , cancer
Recurrent rectal or rectosigmoid cancer is a difficult therapeutic problem. A treatment program of external beam irradiation, surgery, and intraoperative irradiation has been used for 41 patients. The 5‐year actuarial local control and disease‐free survival of all 41 patients was 30% and 16%, respectively. Subset analysis demonstrated differences in outcome by extent of surgical resection. The 5‐year actuarial local control and disease‐free survival of 27 patients undergoing complete resection was 47% and 21%, respectively. By contrast, the outcome of 14 patients undergoing partial resection was poor, with a 5‐year actuarial local control and survival of 21% and 7%, respectively. Late complications included soft tissue or peripheral nerve injury, with many of these resolving within 4–18 months. Local control and disease‐free survival rates are favorable in comparison with the results achieved by aggressive surgery. Patients who achieve a gross total resection at intraoperative irradiation have a markedly better prognosis than that of patients with residual gross disease. © 1995 Wiley‐Liss, Inc.