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Management of lymph node metastases in breast cancer and gastric cancer
Author(s) -
Noguchi Masakuni,
Miyazaki Itsuo
Publication year - 1995
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930600113
Subject(s) - medicine , lymph node , breast cancer , cancer , dissection (medical) , lymph , axillary lymph node dissection , metastasis , oncology , surgery , pathology , sentinel lymph node
The management of regional lymph node metastases in breast cancer and gastric cancer is reviewed. Regional lymph node metastasis is a critical prognostic factor in these diseases, but there is an apparent discrepancy in the efficacy of regional lymph node dissection between them. A number of prospective randomized clinical trials have demonstrated that regional lymph node dissection improves the regional control of breast cancer, but does not improve the survival. On the other hand, only retrospective or prospective comparative studies have shown that extended lymph node dissection significantly improves the survival in gastric cancer. Although the discrepancy in the regional lymph node dissection between breast and gastric cancers has been explained by differences in their biological behaviors, caution must still be exercised in drawing conclusions from these nonrandomized studies. © 1995 Wiley‐Liss, Inc.