Premium
Nuclear DNA content and nucleolar organizer regions in colorectal cancer
Author(s) -
Adachi Yosuke,
Kido Akinori,
Mori Masaki,
Matsushima Tetsuya,
Shimono Reishi,
Inoue Tetsuya,
Sugimachi Keizo
Publication year - 1995
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930590308
Subject(s) - colorectal cancer , nucleolus organizer region , nuclear dna , pathology , medicine , lymph node , metastasis , lymph node metastasis , stage (stratigraphy) , cancer , ploidy , dna , oncology , cancer research , biology , nucleolus , genetics , gene , mitochondrial dna , paleontology , nucleus , psychiatry
The prognostic value of nuclear DNA content and argyrophilic nucleolar organizer regions (AgNOR) is still controversial in colorectal cancer. Sixty patients with colorectal cancer were studied by flow cytometric DNA analysis and AgNOR measurement, and their prognostic significance was tested. DNA index was closely linked to depth of invasion and lymph node metastasis, while AgNOR count did not correlate with such parameters. The survival curve was stongly influenced by depth of invasion, lymph node metastasis, and Dukes' stage but was not affected by DNA ploidy and AgNOR count. These results indicate that neither DNA ploidy nor AgNOR count correlates with survival of patients, although DNA ploidy is linked to progression of colorectal cancer.