Usefulness of platelet‐derived growth factor as a prognostic factor in pulmonary adenocarcinoma | Zendy

Takanami Iwao | Zendy; Yamamoto Yasuki | Zendy; Kodaira Susumu | Zendy; Imamura Tetsuo | Zendy

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Usefulness of platelet‐derived growth factor as a prognostic factor in pulmonary adenocarcinoma

Author(s) -

Takanami Iwao,

Yamamoto Yasuki,

Kodaira Susumu,

Imamura Tetsuo

Publication year - 1995

Publication title -

journal of surgical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.201

H-Index - 111

eISSN - 1096-9098

pISSN - 0022-4790

DOI - 10.1002/jso.2930580109

Subject(s) - platelet derived growth factor receptor , medicine , platelet derived growth factor , growth factor , adenocarcinoma , pulmonary adenocarcinoma , pathology , immunohistochemistry , gastroenterology , cancer , receptor

Platelet‐derived growth factor (PDGF) in the resected pulmonary adenocarcinoma tissue of 88 patients was detected immunohistochemically by the avidin‐biotin‐peroxidase technique to determine whether or not it is a prognostic parameter. The 88 patients were divided into PDGF (‐) and PDGF (+) groups according to the stainability of the factor. The PDGF (‐) group included 39 patients and the PDGF (+) group 49. The 5‐year survival rate was 53% for the PDGF (‐) group and 17% for the PDGF (+) group ( P < 0.01). These findings indicate that the stainability of PDGF can be a prognostic parameter for pulmonary adenocarcinoma. © 1995 Wiley‐Liss, Inc.

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