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Usefulness of platelet‐derived growth factor as a prognostic factor in pulmonary adenocarcinoma
Author(s) -
Takanami Iwao,
Yamamoto Yasuki,
Kodaira Susumu,
Imamura Tetsuo
Publication year - 1995
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930580109
Subject(s) - platelet derived growth factor receptor , medicine , platelet derived growth factor , growth factor , adenocarcinoma , pulmonary adenocarcinoma , pathology , immunohistochemistry , gastroenterology , cancer , receptor
Platelet‐derived growth factor (PDGF) in the resected pulmonary adenocarcinoma tissue of 88 patients was detected immunohistochemically by the avidin‐biotin‐peroxidase technique to determine whether or not it is a prognostic parameter. The 88 patients were divided into PDGF (‐) and PDGF (+) groups according to the stainability of the factor. The PDGF (‐) group included 39 patients and the PDGF (+) group 49. The 5‐year survival rate was 53% for the PDGF (‐) group and 17% for the PDGF (+) group ( P < 0.01). These findings indicate that the stainability of PDGF can be a prognostic parameter for pulmonary adenocarcinoma. © 1995 Wiley‐Liss, Inc.