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Metachronous bladder tumors in patients with upper urinary tract transitional cell carcinoma
Author(s) -
Mukamel Eliahu,
Simon Dan,
Servadio Ciro,
Konichezky Myriam,
Hadar Herzlia,
Edelman Abraham
Publication year - 1994
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930570310
Subject(s) - medicine , transitional cell carcinoma , upper urinary tract , urinary system , urology , carcinoma , urinary bladder , oncology , bladder cancer , cancer
Sixty‐nine patients who underwent nephroureterectomy for upper urinary tract transitional cell carcinoma were included in the study. The following data were collected for each patient: grade and stage of renal/ureteral tumor, tumor location, timing of tumor appearance and recurrence in the bladder, grade and stage of each of the recurrent tumors, and number of recurrences. Follow‐up ranged between 2 and 15 years. Thirty‐three patients (47.8%) developed metachronous bladder tumors. The appearance of the bladder tumors was related to tumor grade and multifocality of the upper urinary tract TCC. Of the 33 patients, 19 had 1 tumor appearance in the bladder, 6 had 2 recurrences, and 8 had 3 recurrences. The 5‐year survival rate for patients with no subsequent bladder tumors was 57% compared to 22% for those who had subsequent tumors. It is concluded that the appearance of bladder tumors following nephroureterectomy characterizes a group of patients with biologically more active disease with unfavorable prognosis. © 1994 Wiley‐Liss, inc.