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Risk analysis of carcinogenesis in the remnant stomach with measurement of ornithine decarboxylase activity
Author(s) -
Kitao Yoshitaka,
Yamane Tetsuro,
Kikuoka Norikazu,
Matsumoto Hirohiko,
Oya Kazuhiko,
Inagake Masao,
Takahashi Toshio
Publication year - 1994
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930570107
Subject(s) - ornithine decarboxylase , billroth i , medicine , stomach , gastrectomy , gastric mucosa , billroth ii , gastroenterology , cancer , chemistry , enzyme , biochemistry
Gastric ornithine decarboxylase (ODC) activity was measured as a biomarker of tumor‐promoting activity in the remnant stomach of rats and humans. Gastrectomy of Wistar rats utilizing the Billroth I method caused a significantly high induction of ODC, and use of the Billroth II method caused a significantly higher induction of ODC than the Billroth I method. In humans, ODC activity of remnant gastric cancer tissue, normal‐appearing mucosa of remnant gastric cancer patient, and remnant gastric mucosa without cancer after the Billroth II method were significantly higher than that of normal gastric mucosa without gastrectomy. ODC activity of remnant gastric mucosa without cancer after the Billroth II method was significantly higher than that after the Billroth I method. Risk of carcinogenesis was high in the remnant stomach, especially after the Billroth II method. © 1994 Wiley‐Liss, Inc.