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Univariate and multivariate analyses of the prognostic significance of discontinuous intramural metastasis in patients with esophageal cancer
Author(s) -
Kuwano Hiroyuki,
Watanabe Masayuki,
Sadanaga Noriaki,
Kamakura Tatsuro,
Nozoe Tadahiro,
Yasuda Mitsuhiro,
Mimori Koshi,
Mori Masaki,
Sugimachi Keizo
Publication year - 1994
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930570106
Subject(s) - medicine , esophageal cancer , univariate analysis , multivariate analysis , esophagus , metastasis , lymph node metastasis , gastroenterology , lesion , carcinoma , oncology , cancer , lymph node , univariate , pathology , multivariate statistics , statistics , mathematics
A review of 167 cases of esophageal carcinoma without preoperative treatment revealed 24 (14.4%) to have intramural metastasis (IM) within the esophagus. Among the clinicopathologic factors, the length of the lesions ( P < 0.01), lymph node metastasis ( P < 0.001), and the depth of the invasion of the tumor ( P < 0.0001) were found to be statistically significant different factors between the two groups of patients both with and without intramural metastasis. The survival curve for patients with IM was significantly lower than that for patients without IM ( P < 0.0001). A univariate analysis revealed that the depth of invasion, lymph node metastasis, IM ( P < 0.0001), and the length of the lesion ( P < 0.001) all had a significant correlation with the prognosis. Moreover, in a multivariate analysis, the depth of the invasion (<0.001), length of the lesion (0.001), and IM (0.049) were all determined to be significant prognostic factors. Therefore, IM is considered to be one of the independent significant prognostic factors for predicting a poor prognosis in esophageal cancer. © 1994 Wiley‐Liss, Inc.