Premium
Silver stained nucleolar organizer region proteins and Helix pomatia agglutinin immunostaining in esophageal carcinoma: Correlated prognostic factors
Author(s) -
Yoshida Yasunori,
Okamura Takeshi,
Yano Kouichi,
Ezaki Takahiro
Publication year - 1994
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930560215
Subject(s) - immunostaining , pathology , helix pomatia , silver stain , medicine , staining , carcinoma , stage (stratigraphy) , lymphovascular invasion , immunohistochemistry , cancer , biology , metastasis , ecology , paleontology , snail
The number of nucleolar organizer region proteins identified by silver staining (AgNORs) and alterations in cell surface glycoproteins identified by Helix pomatia agglutinin (HPA) immunostaining were studied in 96 primary esophageal carcinomas. The number of AgNORs increased with increasing depth of cancer invasion, venous involvement, lymphatic invasion, and tumor stage. Positivity of HPA staining correlated significantly with increasing depth of cancer invasion, venous invasion, and tumor stage. Forty of 42 HPA negative cases had low AgNORs numbers (<4), while 39 of 54 HPA positive cases had high AgNORs numbers (⩾4) ( P = 0.0001). The survival rate of patients with stage III and IV disease was significantly poorer for those with a high AgNORs score and HPA positivity than in those with a low AgNORs score and HPA negativity. The present study indicates that the AgNORs score is positively correlated with positive HPA staining and that tumors having both factors represent a subgroup of esophageal carcinomas with poor prognosis. © 1994 Wiley‐Liss, Inc.