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Immunological profile changes following perioperative autologous vs. homologous blood transfusion in oncologic patients
Author(s) -
Peller Shoshana,
Sayfan Joel,
Levy Yeheskel,
Oland Jan,
Yona Rivka,
Kaufman Suzana,
Orda Ruben
Publication year - 1994
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930560210
Subject(s) - medicine , perioperative , autotransfusion , homologous chromosome , blood transfusion , immune system , concanavalin a , autologous blood , immunology , surgery , gastroenterology , biochemistry , chemistry , in vitro , gene
Abstract To determine the effect of perioperative blood transfusion on immunological parameters, T cells, T‐cell subsets, and concanavalin A‐induced suppression were measured in 25 patients with colorectal and breast cancer. During the operation, 15 patients received autologous blood and 10 patients had homologous transfusion. The immunological status was again determined after curative surgery. Before surgery, normal percentage of T lymphocytes, decreased ratios of helper/suppressor cells, and impaired con A‐induced suppression were found. Following the operation, the helper and suppressor cell percentages reversed to normal, whereas the con A‐induced suppression remained impaired. This change was significantly more pronounced in patients who received autologous blood transfusion than in the other group. Autotransfusion has an impact on immune parameters that might prove less detrimental to the clinical outcome in oncologic surgery than homologous transfusion. © 1994 Wiley‐Liss, Inc.