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Serum CA 125 concentrations in patients with benign ovarian tumours
Author(s) -
Buamah Paul K.,
Skillen Andrew W.
Publication year - 1994
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930560204
Subject(s) - medicine , serous cystadenoma , ascites , malignancy , cystadenoma , meigs' syndrome , mucinous cystadenoma , fibroma , serous fluid , gastroenterology , ovary , pathology , gynecology , pancreas
Abstract Serum CA 125 concentrations have been measured in 115 patients with histologically confirmed nonmalignant pelvic disease, that is, serous cystadenoma (n = 56), mucinous cystadenoma (n = 14), fibroma (n = 33), thecoma (n = 8), and Brenner tumour (n = 4). Increased CA 125 concentrations (> 35 KU/L) were found in 14 patients, with a range of 46–891 KU/L, a mean of 205 KU/L, and a median of 97 KU/L. The highest values were found in patients with ascites. Serial measurements in one patient showed a fall in the 2 days immediately after surgery, over the next 3 days showing a two‐ to three‐fold increase, followed by a slow return to normal over the next 7 weeks. Elevated CA 125 levels may not indicate ovarian malignancy and do not differentiate between benign and malignant pelvic masses. © 1994 Wiley‐Liss, Inc.