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Renal cell carcinoma producing α‐fetoprotein (AFP) with a unique lectins‐affinity profile
Author(s) -
Minamoto Toshinari,
Kitagawa Masanobu,
Amano Naoko,
Tsukada Yutaka,
Hirose Tatsuo,
Mai Masayoshi
Publication year - 1994
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930550404
Subject(s) - concanavalin a , medicine , renal cell carcinoma , pathology , yolk sac , carcinoma , alpha fetoprotein , kidney , concomitant , pathophysiology , cancer research , biology , hepatocellular carcinoma , biochemistry , embryo , in vitro , microbiology and biotechnology
Renal cell carcinoma (RCC) producing α‐fetoprotein (AFP) is a rare entity and merely 7 cases have been reported so far. The present case, a 71‐year‐old woman, showed a high serum AFP level of 204 ng/ml. The RCC of the autopsied right kidney consisted mainly of spindle‐shaped or bizarre sarco‐matous tumor cells. AFP was immunolocalized only in the concomitant clear cell component. Concanavalin A (Con A)‐nonadsorption rate of serum AFP was 42%, which was an intermediate value between those of yolk sac tumors and metastatic liver carcinomas. Lens culinalis agglutinin (LCA)‐affinity study of the patient's AFP showed an unknown peak X, which was eluted between the known peaks 2 and 3. These results suggest a certain structural alteration in carbohydrate moieties of the AFP derived from this RCC. A review of the clincopathologic features of 8 patients with AFP‐producing RCC was made to understand the pathophysiology of AFP‐producing neoplasms. © Wiley‐Liss, Inc.