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Granulosa cell tumor of the ovary: A study of 18 cases
Author(s) -
Piura Benjamin,
Nemet Dan,
YanaiInbar Ilana,
Cohen Yoram,
Glezerman Marek
Publication year - 1994
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930550203
Subject(s) - medicine , stage (stratigraphy) , hysterectomy , surgery , ovary , abdominal hysterectomy , oophorectomy , chemotherapy , adjuvant chemotherapy , gynecology , cancer , breast cancer , biology , paleontology
In a study of 18 patients diagnosed with ovarian granulosa cell tumor between 1961 and 1992, clinical and pathologic findings were evaluated. Of the 18 patients, 15 (83.3%) were diagnosed in Stage I and three (16.7%) in Stage III or IV. Six patients (33.3%) underwent conservative surgery and in 12 (66.7%) total abdominal hysterectomy and bilateral salpingo‐oophorectomy was performed. At follow‐up three patients (16.6%) had died of disease, three, 16 and 288 months, respectively, after initial surgery. The actuarial 5‐year survival rate for Stage I was 100%, while that for Stages III and IV combined was 33.3% ( P < 0.05). It is concluded that for patients with Stage IA, unilateral oophorectomy seems to be adequate treatment and for those with more than Stage IA, surgery should include total abdominal hysterectomy and bilateral salpingo‐oophorectomy. Postoperative adjuvant chemotherapy is advocated for patients in whom spread of tumor beyond the ovaries has occurred. © Wiley‐Liss, Inc.