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Tumor progression accompanied by increase in proliferation rate in breast cancer: A preliminary report
Author(s) -
Sasa Mitsunori,
Komaki Kansei,
Tsuzuki Hideo,
Kamamura Yoshitaka,
Mori Toshiaki,
Miki Hitoshi,
Uyama Tadashi,
Morimoto Tadaoki,
Monden Yasumasa
Publication year - 1993
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930540415
Subject(s) - medicine , proliferating cell nuclear antigen , breast cancer , immunohistochemistry , proliferation marker , proliferation index , pathology , primary tumor , cancer , breast tumor , proliferative index , stage (stratigraphy) , mammary gland , oncology , cancer research , metastasis , biology , paleontology
Forty consecutive cases with invasive ductal carcinoma of the breast (samples of both the primary invasive area and the involved node were available for 19 cases, multiple sections of breast tissue including both the primary invasive area and forefront intraductal cancerous area were available for 15 cases; and multiple sections of breast cancerous tissue and the involved node were available for six cases) were examined by immunohistochemical analysis for evaluation of their proliferation rate. In this study, we selected the PCNA index as a marker of the proliferation rate of the tumor cells. We demonstrated that the PCNA index of the primary invasive area was significantly higher than that of the forefront intraductal area ( P – 0.0017), and the PCNA index of the involved nodes was significantly higher than that of the primary invasive area ( P = 0.0004). These preliminary findings suggest that the progression from the tumor cells of the intraductal cancerous area to the metastatic tumor cells must be accompanied by two phases of increase in the proliferation rate. © 1993 Wiley‐Liss, Inc.