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Growth inhibition of human gastrointestinal cancer xenograft lines by treatment with CPT‐11 and VP‐16
Author(s) -
Nagai Satoshi,
Yamauchi Masaji,
Satta Tetsuya,
Kodera Yasuhiro,
Kondou Ken,
Akiyaya Seiji,
Ito Katsuki,
Takagi Hiroshi
Publication year - 1993
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930540404
Subject(s) - medicine , gastrointestinal cancer , cancer , oncology , cancer research , growth inhibition , colorectal cancer , cell culture , biology , genetics
A water‐soluble and stable camptothecin derivative, CPT‐11, was found to possess a strong antitumor activity against various murine tumors. In the present study, CPT‐11 was tested against ten human gastrointestinal cancer xenograft lines carried by nude mice. CPT‐11 was very effective against nine xenograft lines, with the exception of one xenograft. On the other hand, VP‐16 was ineffective against all these xenograft lines. Therefore, CPT‐11 is expected to be clinically more effective against gastrointestinal cancer than the topo II targeting agent. © 1993 Wiley‐Liss, Inc.