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Pancreatic ductal cell carcinoma producing pancreatic elastase 1
Author(s) -
Iwase Kazuhiro,
Miyata Masahiko,
Yamaguchi Tokio,
Kawaguchi Takanobu,
Tanaka Yasuhiro,
Matsuda Hikaru
Publication year - 1993
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930540316
Subject(s) - medicine , elastase , pancreas , pancreatic carcinoma , pancreatic elastase , pancreatic cancer , pancreatectomy , pathology , ductal cells , metastasis , pancreatitis , carcinoma , concomitant , cancer , enzyme , biology , biochemistry
The elevation of plasma pancreatic elastase 1 in patients with pancreatic cancer is caused by concomitant pancreatitis. There is no report that pancreatic ductal cell carcinoma tissue itself produced elastase 1. A 54‐year‐old woman underwent total pancreatectomy for pancreatic ductal cell carcinoma. Her plasma elastase 1 level subsequently decreased from the preoperative value of 406 ng/dl to values ranging between 96 ng/dl and 119 ng/dl, until 6 months after the operation, when it began to increase gradually to a maximum of 300 ng/dl in association with local recurrence and hepatic metastasis. Immunohistochemical staining of elastase 1 was positive in the primary tumor resected at operation as well as in the locally recurrent and hepatic metastatic tumors obtained at autopsy. These findings suggested that elastase 1 was produced by the tumor cells in this patient. This is the first case in which pancreatic ductal cell carcinoma cells produced elastase 1. © 1993 Wiley‐Liss, Inc.