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Hepatic tumor and tumor‐like lesions in childhood
Author(s) -
Callea Francesco,
Bonetti Mariafausta,
Medicina Daniela,
Alberti Daniele,
Fabbretti Giovanna,
Brisigotti Massimo
Publication year - 1993
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930530545
Subject(s) - medicine , hepatic tumor , pathology
Tumors of the liver are rare in infancy and childhood. Some are peculiar to the pediatric age, e.g., hepatoblastoma, infantile hemangioendothelioma, mesenchymal hamartoma, embryonal rhabdomyosarcoma. This review is based upon personal experience with a series of 32 cases. On the basis of the histological features it is proposed that focal modular hyperplasia (FNH) and mesenchymal hamartoma be considered as tumor‐like lesions rather than true neoplasms. A few benign epithelial lesions (FNH, adenoma) were associated with inborn error of metabolism. In half of the patients, hepatocellular carcinoma (HCC) developed in perinatally hepatitis B virus (HBV)‐infected children. HCC developed in a noncirrhotic liver in a single patient, in whom HB V‐DNA integration had occurred. © 1993 Wiley‐Liss, Inc.