Premium
Pathology of hepatocellular carcinoma
Author(s) -
Callea Francesco,
Favret Maurizio,
Marino Carla,
Brisigotti Massimo
Publication year - 1993
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930530544
Subject(s) - hepatocellular carcinoma , medicine , pathology , pathognomonic , immunocytochemistry , cytokeratin , immunohistochemistry , fibrinogen , clone (java method) , antigen , carcinoma , hepatitis b virus , metastatic carcinoma , virus , cancer research , immunology , biology , disease , gene , biochemistry
This study provides a guideline to a dynamic approach toward the diagnosis of hepatocellular carcinoma (HCC). Bile production, fibrinogen synthesis, Mallory body, fibrinogen ground‐glass and abnormal glycogen bodies as a reflection of “clone” selection, and hepatitis B virus (HBV) antigen expression in tumer cells can be considered as markers for the morphological diagnosis of HCC. The demonstration in tumor cells of these diagnostic features requires a careful screening of routinely stained preparations in search of suggestive, characteristic, specific, or pathognomonic features further supplemented by ancillary techniques, such as histochemistry, immunocytochemistry, and electron microscopy. © 1993 Wiley‐Liss, Inc.