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Efficacy of chemoembolization for hepatocellular carcinomas: Experience from the gustave roussy institute and the bicetre hospital
Author(s) -
Rougier Philippe,
Roche Alain,
Pelletier Gilles,
Ducreux Michel,
Pig Jean Pierre,
Etienne Jean Pierre
Publication year - 1993
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930530526
Subject(s) - lipiodol , medicine , hepatocellular carcinoma , doxorubicin , survival rate , gastroenterology , surgery , randomized controlled trial , overall survival , chemotherapy
Chemoembolization (CE) has been used for more than 10 years to treat hepatocellular carcinoma (HCC) in our departments, and three studies have been done. The first was a retrospective study on 232 patients in which CE was performed with doxorubicin and Gelfoam with or without Lipiodol; the response rate was 41% (34.7–47.3%) and survival was better for Okuda stage I disease than for stages II and HI (2‐year survival 82, 29, and 0% respectively); for patients with Lipiodol retention the response rate was over 50%. The second study compared CE with doxorubicin and Gelfoam to symptomatic treatment in a randomized manner; it included 42 patients and failed to demonstrate a survival advantage (1‐year survival: CE 24% vs. control 31%; NS). The third study is ongoing and tests CE with cis‐platinum, Lipiodol, and Gelfoam. According to our experience prospective randomized studies are warranted to define clearly the best indications for CE in HCC. © 1993 Wiley‐Liss, Inc.