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Orthotopic liver transplantation in primary liver tumors
Author(s) -
MorenoGonzález Enrique,
Loinaz Carmelo,
Gómez Ramon,
Garclá Ignacio,
GonzálezPinto Ignacio,
Jiménez Carlos,
Maffettone Vincenzo,
Colina Francesco,
Palomo Juan Carlos,
Vorwald Peter,
Musella Mario
Publication year - 1993
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930530521
Subject(s) - medicine , liver transplantation , primary (astronomy) , orthotopic liver transplantation , transplantation , general surgery , pathology , physics , astronomy
Abstract Among 283 orthotopic liver transplantations made during the last 6 years at our institution, 22 (7.77%) were done on 19 patients with unresectable hepatic malignant tumors [hepatocellular carcinoma (17), angiosarcoma (1), and cholangiocarcinoma (1)]. None of them showed extrahepatic invasion, and only one had lymph node involvement. Cyclosporin A, corticosteroids, and azathioprine were administered for 3 months after the procedure, and maintenance therapy involved the first two drugs. Acute rejection rate and hospital stay were not significantly different compared with non–tumoral grafted patients. Three patients were retransplanted, one with uncontrolled acute rejection and two with chronic rejection. Intraoperative mortality was zero. Eight patients (42.1%) were alive at a mean follow‐up of 31 months (range, 6–74). Four 22.2%) died with tumor recurrence, three of sepsis, two of respiratory insufficiency, one of hepatitis recurrence with cirrhosis, and one of primary lung neoplasia. If adequately selected, primary liver tumor patients may benefit from liver transplantation. Future research with adjuvant therapies will improve the results. © 1993 Wiley‐Liss, Inc.