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Surgical risk in alcoholic cirrhotic postmenopausal women: Prognostic value of levels of hormones
Author(s) -
Gavaler Judith S.,
van Thiel David H.,
Deal Stephen R.
Publication year - 1993
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930530515
Subject(s) - medicine , prolactin , testosterone (patch) , cirrhosis , luteinizing hormone , hormone , hepatic encephalopathy , liver transplantation , alcoholic liver disease , transplantation , gastroenterology , encephalopathy , endocrinology , physiology
Because increased prolactin levels and hyperprolactinemia in the presence of encephalopathy in males with cirrhosis (alcohol‐induced cirrhosis in particular) are associated with statistically increased mortality, we have examined pre‐surgical levels of prolactin and other hormones, as well as the presence of encephalopathy, in 12 postmenopausal women with endstage alcohol‐induced cirrhosis in relation to liver transplant survival. Levels of estradiol were significantly lower, while luteinizing hormone (LH) and 17‐hydroxyprogesterone as well as the ratio of estradiol to testosterone were significantly higher prior to transplantation among the women who survived, compared with non‐survivors. A similar pattern was seen for transplant candidates who died before transplantation as compared with still‐living candidates. These findings suggest that pre‐operative levels of sex steroids and pituitary hormones may have prognostic value in alcoholic cirrhotic postmenopausal women undergoing liver transplantation. © 1993 Wiley‐Liss, Inc.