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Studies in vitro on the influence of ursodeoxycholate sodium salt (UDC) on hepatocyte proliferation
Author(s) -
Barone Michele,
Panella Carmine,
Ancelini Annamaria,
Romanelli Domenica,
Francavilla Antonio
Publication year - 1993
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930530504
Subject(s) - hepatocyte , in vitro , medicine , sodium , salt (chemistry) , sodium salt , pharmacology , biochemistry , chemistry , inorganic chemistry , organic chemistry
In this study the influence of sodium ursodeoxycholate (UDC) on hepatocyte replicative activity was evaluated using quiescent or primed hepato‐cytes obtained from normal rats or from rats fed with a protein‐free diet, respectively. At physiological concentrations UDC stimulated proliferation in quiescent or primed hepatocytes cultured in minimum essential medium plus insulin, and augmented the replicative activity in hepatocytes already stimulated by low concentration of epidermal growth factor and normal rat serum. However, UDC was not the only bile salt (BS) to show this stimulatory effect on hepatocyte proliferation. The stimulatory activity of BSs was not correlated with their degree of hydrophilia. © 1993 Wiley‐Liss, Inc.