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Testicular seminoma stage I: Treatment results and long‐term follow‐up (1968–1988)
Author(s) -
Stein Moshe Efraim,
Kessel Ivan,
Luberant Norman,
Kuten Avraham
Publication year - 1993
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930530309
Subject(s) - seminoma , medicine , radiation therapy , stage (stratigraphy) , surgery , chemotherapy , dysgerminoma , paleontology , biology , ovary
Sixty‐nine patients with stage I testicular seminoma were referred to the Northern Israel Oncology Center between 1968 and 1987. Sixty‐four patients were irradiated postoperatively and five patients had surveillance alone. Complete follow‐up was available for all patients, with a median follow‐up of 86 months (range 9–239 months). The last follow‐up was in December 1988. Actuarial survival was 94% to 5, 10, 15, and 20 years. Six patients relapsed following completion of irradiation. All the recurrences occurred outside the radiation field. Three of the relapsed patients could be salvaged with cisplatinum‐based chemotherapy and are alive at 4, 7, and 10 years following second‐line treatment. Acute or chronic side effects were mild and manageable. Seven patients developed second primary cancers, two within and six outside the radiation field. While surveillance policy alone in stage I testicular seminoma may be successful in terms of patient outcome, it requires prolonged observation, good compliance of patients, and intensive use of resources. Thus, until proved otherwise, infradiaphragmatic radiotherapy should further remain the optimal routine treatment in seminoma patients with stage I disease. © 1993 Wiley‐Liss, Inc.