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An experimental recurrence model for malignant fibrous histiocytoma induced by 4‐hydroxyaminoquinoline 1‐oxide in the rat
Author(s) -
Tanuma Masaji,
Goto Kunihiko,
Nagura Hiroshi,
Sakurai Minoru
Publication year - 1993
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930520413
Subject(s) - medicine , doubling time , mitotic index , rat model , pathology , surgery , mitosis , cell culture , biology , genetics , microbiology and biotechnology
To clarify the relationship between local recurrence of mesenchymal tumors and their malignant potentiality, we made an experimental recurrence model for malignant fibrous histiocytoma (MFH) induced by 4‐hydroxyaminoquinoline 1‐oxide in the rat by repeated exicisional operations. By the repeated exicision, the number of recurrent tumors increased, and the doubling time of tumor growth was shortened. The mean doubling time of primary tumors was 6.6 days, that of the first locally recurrent tumors was 4.3 days, and that of the second locally recurrent tumors was 3.3 days. However, mitotic count and 5‐bromo‐2‐deoxyuridine (BrdU) labeling index did not change. this study proved experimentally that MFH shows more rapid growth through repeated local recurrences, and this experimental model may provide a better understanding of the local recurrence of MFH. © 1993 Wiley‐Liss, Inc.