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Changing role of splenectomy for hematologic disease
Author(s) -
Marble Kimberly R.,
Deckers Peter J.,
Kern Kenneth A.
Publication year - 1993
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930520310
Subject(s) - medicine , splenectomy , cytopenia , hematologic disease , anemia , surgery , disease , laparotomy , pediatrics , spleen , bone marrow
In the past decade the development of accurate imaging and the evolution of the medical management of hematologic diseases has led to changes in the indications for splenectomy for these disorders. To assess the impact of these developments, a multi‐institutional, retrospective review was undertaken. One hundred fifty‐six splenectomies were performed for hematologic disorders between July 1, 1979 and June 30, 1991. Patients were divided into 2 groups: those undergoing splenectomy from 1979–1985 (Period I), and those undergoing splenectomy from 1986–1991 (Period 11). Diseases were classified into 3 groups: cytopenic/anemic conditions, symptomatic splenomegaly, and Hodgkin's disease. Data was compared between the two periods using chi‐square analysis. More splenectomies were performed for hematologic disorders during Period II than Period I ( P < .005). This increase is secondary to a rise in the number of splenectomies performed for cytopenidanemia during Period II. In contrast, splenectomies for splenomegaly and Hodgkin's disease decreased during Period II ( P < .005 and < .05). More Hodgkin's patients were upstaged on the basis of positive laparotomy findings in Period II, compared to Period I (40% versus 10%, P = .01). Surgeons are now performing more splenectomies for cytopenic/anemic diseases, and fewer for splenomegaly and Hodgkin's disease. These results are consistent with recent trends: (1) earlier splenectomy in patients with cytopenidanemia; (2) earlier medical intervention in infiltrative splenic disorders; and (3) more reliance on radiologic staging in Hodgkin's disease and widespread use of combination chemotherapy, leaving surgical staging for those cases in which treatment would be changed by laparotomy findings. © 1993 Wiley‐Liss, Inc.