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Prediction of operative mortality based on impairment of host defense systems in patients with esophageal cancer
Author(s) -
Saito Takao,
Shimoda Katsuhiro,
Kinoshita Tadahiko,
Shicemitsu Yuji,
Miyahara Masaki,
Kobayashi Michio,
Shimaoka Akira
Publication year - 1993
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930520103
Subject(s) - medicine , esophageal cancer , esophagectomy , perioperative , cancer , intensive care medicine , surgery , oncology
To determine whether operative risk based on impaired defense systems can be predicted, we examined 21 markers in 32 patients with esophageal cancer seen between 1983 and 1985 and related them to postoperative deaths. A discriminant analysis proved useful in determining whether the patient would be at risk of operative mortality, based on impaired defense systems. This model, the host defense index (HDI), was then used clinically to evaluate findings in 64 patients seen between 1986 and 1991. During this period, a change in policy for performing transthoracic esophagectomy on and perioperative care for patients with impaired defense systems was associated with a decrease in operative mortality. Thus, the HDI is beneficial to predict the risk of operative mortality based on impaired defense systems in patients with esophageal cancer. © 1993 Wiley‐Liss, Inc.