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The effect of vagotomy and pyloroplasty on colorectal tumor induction in the rat
Author(s) -
Nelson Richard L.,
Briley Susan,
Vaz Octavio P.,
Abcarian Hercand
Publication year - 1992
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930510416
Subject(s) - pyloroplasty , medicine , vagotomy , colorectal cancer , laparotomy , gastroenterology , incidence (geometry) , cancer , surgery , physics , optics
Epidemiologic studies have suggested that vagotomy increases subsequent colorectal cancer risk. This hypothesis was investigated in the rat 1,2 dimethylhydrazine (DMH) colorectal carcinogenesis model. Eighty‐five rats were divided into four groups having either truncal vagotomy and Heineke‐Mickulicz pyloroplasty, pyloroplasty alone, laparotomy alone, and anesthesia alone. After recovery from the procedures, colon tumors were induced with five injections of DMH. Results of carcinogenesis show a trend towards increased incidence and yield of colorectal and duodenal tumors after vagotomy, though this was not statistically significant, perhaps because the high postoperative mortality from vagotomy diminished the power of the Study. © 1992 Wiley‐Liss, Inc.