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Synergistic effects of intratumor administration of cis‐diamminedichloroplatinum(II) combined with local hyperthermia in melanoma bearing mice
Author(s) -
Kitamura Kaoru,
Kuwano Hiroyuki,
Matsuda Hiroyuki,
Toh Yasushi,
Masuda Hidetaka,
Sugimachi Keizo
Publication year - 1992
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930510313
Subject(s) - medicine , hyperthermia , melanoma , chemotherapy , systemic administration , metastasis , significant difference , intraperitoneal injection , urology , pharmacology , cancer research , cancer , biology , microbiology and biotechnology , in vivo
The synergistic effect of local hyperthermia (LHT) with intratumor injection (i.t.) of cis‐diamminedichloroplatinum (II) (DDP) was studied using a rodent model with implanted B16 melanoma tumors. The hindfoot of the C57BL/6 mouse bearing the tumor was placed in a water bath at 42.5 ± 0.2°C (intratumor temperature was at 42.3 ± 0.1°C) for 30 minutes just after local (i.t.) or systemic (intraperitoneal;i.p.) administration of DDP (1‐3 mg/kg once in experiment I and 1‐3 mg/kg three times in experiment II). The tumor growth ratio (TGR) at 7 days after treatment in the group given DDP 3 mg/kg (i.t.) with LHT was 1.1 in experiment I and 0.5 in experiment II, and there was a statistically significant difference in both experiments compared to findings in other groups ( P < 0.01). The mean survival time was 42.1 days in experiment I and 50.2 days in experiment II, with a significant difference in the latter ( P < 0.001). Thus regional injection chemotherapy given concomitantly with local hyperthermia promotes the anticancer effects and improves the prognosis without either severe renal injury or the promotion of hematogenic metastasis. © 1992 Wiley‐Liss, Inc.