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Prognostic factors for noncurative gastric cancer: Univariate and multivariate analyses
Author(s) -
Baba Hideo,
Okuyama Toshiro,
Hiroyuki Orita,
Anai Hideaki,
Korenaga Daisuke,
Maehara Yoshihiko,
Akazawa Kohei,
Sugimachi Keizo,
Lawrence Walter
Publication year - 1992
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930510208
Subject(s) - medicine , lymphadenectomy , multivariate analysis , univariate analysis , metastasis , gastrectomy , lymph node , lymphovascular invasion , cancer , oncology , surgery , gastroenterology
We performed univariate and multivariate analyses of possible prognostic factors related to postoperative clinical course of patients with advanced gastric cancer. Noncurative resection was done for 119 patients with hepatic metastasis, peritoneal seeding, extensive lymph node metastasis, or direct invasion to adjacent organs, either alone or in various combinations. In the univariate analysis, 6 of 17 items such as peritoneal seeding, lymphatic invasion, vascular invasion, mode of invasion, extent of lymphadenectomy, and width of serosal invasion significantly correlated to the prognosis. The multivariate analysis indicated that three inherent pathologic factors, mode of invasion, lymph node metastasis, and hepatic metastasis, and one treatment factor, extent of lymphadenectomy, were significant variables predictive of the prognosis and that the prognosis was expected to be very poor in cases of infiltrative type, nodal involvement to tertiary nodes, presence of hepatic metastasis, and lymphadenectomy less than R3. Prognosis in terms of the extent of lymphadenectomy shows that extensive lymphadenectomy (R3) proved to be significantly effective in prolonging survival time, even after noncurative gastrectomy. We recommend extensive lymphadenectomy to prolong survival time for such patients. © 1992 Wiley‐Liss, Inc.