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Pre‐ and postoperative sequential study on the serum gastrin level in patients with lung cancer
Author(s) -
Zhou Qinghua,
Zhang Huaibin,
Pang Xiaojie,
Yang Junjie,
Tain Zipu,
Wu Zhu,
Yang Zhenhua
Publication year - 1992
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930510108
Subject(s) - medicine , lung cancer , gastrin , radioimmunoassay , cancer , lung , lymph node , gastroenterology , pathology , oncology , secretion
Serial changes in serum gastrin level were detected by radioimmunoassay in 58 lung cancer patients before and after operation. In comparing these tests with those of 40 cases of noncancerous thoracic lesions and 151 normal adults, the serum gastrin from lung cancer patients is significantly higher than that of noncancerous thoracic lesions and normal individuals ( P < 0.01). The gastrin level is closely related to stage of cancer, size of primary tumor, presence of lymph node metastasis, and type of histological classification. The serum gastrin was found to decrease gradually after the removal of the tumor and to return to normal on the 14th postoperative day. Those patients whose serum gastrin level can return to normal on the 14th postoperative day will have a good prognosis; if not, their prognosis will be very poor. These results suggest that serum from patients with lung cancer contains a high concentration of gastrin that can help differentiate benign from malignant thoracic lesions and evaluate prognosis of patients with lung cancer. Therefore, the cause of high serum gastrin in patients with lung cancer is likely due to the gastrin‐producing property of the lung cancer cells. © 1992 Wiley‐Liss, Inc.