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Regional DNA content heterogeneity in colonic adenocarcinoma: Prognostic significance in patients with liver metastases
Author(s) -
Graham Roger A.,
Teague Kim,
McLemore Donia,
Cleary Karen,
ElNaggar Adel
Publication year - 1992
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930500406
Subject(s) - medicine , lymph node , lymph , pathology , flow cytometry , primary tumor , adenocarcinoma , ploidy , metastasis , colorectal cancer , gastroenterology , oncology , cancer , biology , gene , immunology , biochemistry
We retrospectively examined by flow cytometry the DNA ploidy pattern in tissue blocks from 25 primary colon adenocarcinomas and their lymph node and liver metastases. Intratumoral heterogeneity was present in 22% of primary tumors and 21% of metastatic liver deposits. Intertumoral heterogeneity, measured between the primary tumor and its lymph node and liver metastases, was 0% and 20%, respectively. Of 24 patients who underwent successful resection of their liver metastases, 8 neoplasms had uniformly diploid DNA content, while 16 tumors had aneuploid DNA pattern in either the primary tumor, the metastases, or both. Five‐year survival was better in the diploid group (38% vs. 7%, P = 0.10 by log rank analysis). Three of eight patients in the diploid group remain free of disease, while all 16 patients with aneuploid cell populations have died of recurrent disease. © 1992 Wiley‐Liss, Inc.