Premium
Long‐ and short‐term survivors after pancreatoduodenectomy for ampullary carcinoma
Author(s) -
Yamaguchi Koji,
Nishihara Kazuyoshi
Publication year - 1992
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930500314
Subject(s) - medicine , pancreaticoduodenectomy , surgery , perineural invasion , ampulla of vater , carcinoma , multivariate analysis , carcinoembryonic antigen , gastroenterology , cancer , resection
Abstract Out of 36 consecutive patients who underwent a pancreatoduodenectomy for carcinoma of the ampulla of Vater, eight patients (long‐term survivors) survived more than 5 years after surgery, while eight other patients (short‐term survivors) survived less than 12 months after intervention. Both the eight long‐term survivors and eight short‐term survivors were compared clinicopathologically. The long‐term survivors did have some preferable factors such as a high value of peripheral lymphocytes, a low concentration of carcinoembryonic antigen, a small protruding tumor, a shallow depth of invasion, a well‐differentiated histopathologic type, an infrequent venous invasion, and no perineural infiltration. However, these differences were not significant. A multivariate regression analysis regarding the 18 prognostic variables showed that both perineural invasion and the grade of histopathologic differentiation were significant parameters. Out of the eight long‐term survivors, three patients lived more than 10 years while another died from ampullary carcinoma 74 months after surgery. Pancreatoduodenectomy not only produces long‐term survivors but can also effect a complete cure in patients with ampullary carcinoma. A long clinical follow‐up of more than 5 years after surgical intervention is thus warranted. © 1992 Wiley‐Liss, Inc.