Premium
Postoperative adjuvant chemotherapy for operable esophageal cancer: A pilot clinical study
Author(s) -
Sharma Sanjay,
D'Cruz Anil K.,
Kannan Rajan,
Vyas Jatendra J.
Publication year - 1992
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930500209
Subject(s) - medicine , chemotherapy , esophageal cancer , adjuvant chemotherapy , adjuvant , oncology , cancer , surgery , general surgery , breast cancer
Thirty‐eight patients with node positive squamous cell carcinoma of the esophagus were entered into a pilot clinical study using postoperative adjuvant chemotherapy (cisplatinum 100 mg/m 2 and methotrexate 150 mg/m 2 × 4 cycles) with an intent of improving cure rates and overall survival. Patient compliance was excellent and toxicity minimal. At 24 months of follow‐up 22 patients (58%) were disease free, while 14 patients (37%) have relapsed and 2 were lost to follow‐up. A highly significant correlation was noted between the number of nodes involved, the grade of the tumour, and the response to chemotherapy. Patients with poorly differentiated tumours and those with more than 4 nodes involved were more likely to develop recurrent disease ( P < 0.01 and P < 0.005). We conclude that postoperative chemotherapy following resection for carcinoma of the esophagus is well tolerated with minimal side effects. It may also have an impact on improving disease free and overall survival. © 1992 Wiley‐Liss, Inc.