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Melanocyte chemotactic factor produced by skin metastases of a breast carcinoma
Author(s) -
Konomi Kohki,
Imayama Shuhei,
Nagae Shonosuke,
Terasaka Reiji,
Chijiiwa Kazuo,
Yashima Yutaka
Publication year - 1992
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930500117
Subject(s) - medicine , melanocyte , breast carcinoma , metastasis , carcinoma , pathology , biopsy , population , lesion , melanoma , breast cancer , cancer , cancer research , environmental health
A 65‐year‐old woman underwent right modified radical mastectomy for a malignant lesion which had developed just below the right nipple. Two years after the operation, skin lesions composed of dark brown to black, pigmented, papular lesions developed in the precordia. A biopsy revealed this to be a cutaneous metastasis of the previous breast carcinoma. However numerous pigment blockade melanocytes were also found in the tumor nests, located in and/or beneath the epidermis. Although a black‐colored breast carcinoma has been reported, the presence of pigment blockade melanocytes was not determined. Culture of the tumor nest recovered a population of melanocytes as well as the carcinoma cells. Boyden chamber analysis revealed the presence of a chemotactic factor for melanocytes in the culture medium. This seems to be the first documentation of melanocyte incorporation in breast carcinoma tissue. © 1992 Wiley‐Liss, Inc.