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Clinicopathological significance of c‐erbB‐2 protein expression in human gastric carcinoma
Author(s) -
Tateishi Masahiro,
Toda Tomohiro,
Minamisono Yoshikazu,
Nagasaki Susumu
Publication year - 1992
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930490402
Subject(s) - adenocarcinoma , immunohistochemistry , medicine , staining , pathology , positive staining , stomach , gastric carcinoma , cancer , carcinoma , stomach cancer , papillary adenocarcinoma , clinical significance , human stomach , gastroenterology
One hundred seventy‐nine primary human gastric tumors not associated with early cancer or noncurative resection were examined immunohistochemically for the expression of c‐erbB‐2 protein. Positive staining, regarded as an indication of gene amplification, was evident in 22 (12%) of the tumors. Of various clinicopathological factors considered, a statistically significant difference in association with frequency of expression was noted only for histological differentiation, as follows: 39% positive staining in papillary, 17% in well differentiated, 5% in moderately differentiated, and 4% in undifferentiated adenocarcinomas (P > 0.01). The 5‐year survival rates of patients with positive and negative c‐erbB‐2 staining were 57% and 59%, respectively. These findings indicate that, in the case of human gastric adenocarcinoma, expression of c‐erbB‐2 protein is correlated with tumor histological differentiation. Our results also suggest that the presence or absence of c‐erbB‐2 protein may not serve as a prognostic indicator, particularly in cases of adenocarcinoma of the stomach. © 1992 Wiley‐Liss, Inc.