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Surgical approach and sandwich radiotherapy for resectable rectal cancer: Advantages and problems
Author(s) -
Picciocchi Aurelio,
Magistrelli Paolo,
Coco Claudio,
Masetti Riccardo,
Roncolini Giuliano,
Perrotti Pasquale,
Cellini Numa,
Valentini Vincenzo
Publication year - 1991
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930480530
Subject(s) - medicine , radiation therapy , rectum , surgery , stage (stratigraphy) , adenocarcinoma , survival rate , grading (engineering) , cancer , paleontology , civil engineering , engineering , biology
One hundred and twelve patients with locally advanced adenocarcinoma of the rectum have been treated with a protocol of adjuvant radiotherapy from 1981 to 1989. Radiotherapy was administered with a „sandwich” method at a dosage of 2700 cGy preoperatively and of 1800 cGy post‐operatively. Only patients in stages B and C have been considered for results. Postoperative morbidity has been 16% and postoperative mortality 2.7%. Local failure was seen in 20% of patients without significant differences by stage, location, grading and operative technique. Distant metastases were seen in 31% of patients. Five‐year actuarial survival was 49% and respectively 58% in stage B and 38% in stage C ( P < 0.01). Compared with a series of historical controls treated with surgery alone, the local recurrence rate was 20% vs. 26%, the distant metastases rate was 31% vs. 38% and the five‐year actuarial survival rate was 49% vs. 36% ( P > 0.01).