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Cytoreductive surgery impedes metastasis and enhances the immune response: A preliminary report
Author(s) -
Grinis Gedas,
Targonski Paul,
Shaw Michael,
Rubenstein Marvin,
Guinan Patrick D.
Publication year - 1991
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930480210
Subject(s) - medicine , cyclophosphamide , cytoreductive surgery , immune system , adjuvant , metastasis , lung , surgery , oncology , complete response , chemotherapy , immunology , cancer , ovarian cancer
In an effort to determine the effect of cytoreductive surgery on the metastatic process, MAT‐LyLu flank tumors were excised from Copenhagen X Fischer rats and the effects of this surgery on metastatic lung lesions were observed. Cytoreduction resulted in a decrease in lung lesions ( P < 0.05). Adjuvant cyclophosphamide (CTX) further enhanced this beneficial effect. A concurrent increase in the helper/suppressor ratios suggested that this beneficial response might be mediated by the host's immune response.