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Patterns of DNA‐ploidy in operable colorectal carcinoma: A prospective study of 100 cases
Author(s) -
Russo Antonio,
Bazan Viviana,
Plaja Sergio,
Leonardi Patricia,
Bazan Pietro
Publication year - 1991
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930480103
Subject(s) - aneuploidy , rectum , medicine , ploidy , adenocarcinoma , prospective cohort study , pathological , gastroenterology , flow cytometry , pathology , carcinoma , colorectal cancer , dna , oncology , cancer , biology , chromosome , immunology , genetics , gene
A prospective study of cellular DNA content was made by means of flow cytometry in a nonconsecutive series of 100 patients undergoing surgery for primary colorectal adenocarcinoma. DNA‐aneuploidy was present in 80% of cases (80/100); 39% of these were multiclonal (31/80). There was no significant correlation between DNA‐ploidy and the clinical and pathological features examined, except for the primary tumor site (right colon vs. left colon vs. rectum: P <0.001). After a minimum follow‐up of 30 months, out of 40 patients with no local invasion and/or distant metastases, 100% (9/9) of those with DNA‐diploid neoplasias showed no signs of disease relapse, vs. 55% (17/31) of the DNA‐aneuploid cases ( P <0.05). Furthermore, in 45 cases with a minimum follow‐up of 30 months, overall survival was 90% in patients with DNA‐diploid carcinomas and 43% in the DNA‐aneuploid cases ( P <0.05).